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61.
Leonard Tedong Padma Madiraju Louis C. Martineau Diane Vallerand John T. Arnason Dzeufiet D. P. Desire Louis Lavoie Pierre Kamtchouing Pierre S. Haddad 《Molecular nutrition & food research》2010,54(12):1753-1762
Scope: Products of cashew tree (Anacardium occidentale) are used in traditional medicine for various ailments, including diabetes. Methods and results: The anti‐diabetic properties of cashew plant parts were studied using differentiated C2C12 myoblasts (myotubes) and rat liver mitochondria. Hydroethanolic extract of cashew seed (CSE) and its active component, anacardic acid (AA), stimulated glucose transport into C2C12 myotubes in a concentration‐dependent manner. Extracts of other parts (leaves, bark and apple) of cashew plant were inactive. Significant synergistic effect on glucose uptake with insulin was noticed at 100 μg/mL CSE. CSE and AA caused activation of adenosine monophosphate‐activated protein kinase in C2C12 myotubes after 6 h of incubation. No significant effect was noticed on Akt and insulin receptor phosphorylation. Both CSE and AA exerted significant uncoupling of succinate‐stimulated respiration in rat liver mitochondria. Conclusion: Activation of adenosine monophosphate‐activated protein kinase by CSE and AA likely increases plasma membrane glucose transporters, resulting in elevated glucose uptake. In addition, the dysfunction of mitochondrial oxidative phosphorylation may enhance glycolysis and contribute to increased glucose uptake. These results collectively suggest that CSE may be a potential anti‐diabetic nutraceutical. 相似文献
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David Gatineau Jean-Philippe Goddard Virginie Mouriès-Mansuy Louis Fensterbank 《Israel journal of chemistry》2013,53(11-12):892-900
Thanks to their unique electronic and steric properties, carbene ligands offer highly valuable features for catalysis, including homogenous gold catalysis. The use of carbene-gold complexes has improved existing reactions, either by modifying reactivity modes or by leading to highly asymmetric processes. These topics will be discussed on the basis of selected examples. 相似文献
64.
Louis H. Sharpe 《The Journal of Adhesion》2013,89(1-2):15-21
Some criticism is directed at current approaches to composite response which do not include a mechanical model of the region in the vicinity of the interface. An interphase model based on interface roughness is suggested. 相似文献
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In Part I of the paper ((1999), Trib. Trans., 42, pp. 851–859) we investigated the effect of the polyethylene concentration on the film forming properties in a rolling bearing. This second part presents the influence of the polymer additive concentration on the traction behavior experienced using a two-disk machine at different temperatures and contact pressures. By using the traction data, a semi-empirical approach for determining the effective lubricant theological parameters in EHL contacts was performed. Using this approach, the effect of polymer concentration upon rheological parameters that appear in the Johnson and Tevaarwerk model with Eyring stress was quantified. 相似文献
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